Cat. No.: 5191SAXI
Saxitoxin (STX) is a neurotoxic tetrahydropurine of the paralytic shellfish poisoning (PSP) toxin group from poisonous mussels, clams and crustaceans. It binds to the sodium channel of the nerve preventing the passage of sodium ions through the cell membrane and therefore blocks passage of the nerve impulse. Exposure to STX typically comes from eating shellfish contaminated by “red tides” or algal blooms of Alexandrium catenella (formerly Gonyaulax catenella) or A. tamarense-excavatum (formerly G. tamarensis).
STX is readily soluble in water and can be dispersed in aerosols. It is toxic by ingestion and by inhalation, with inhalation leading to rapid respiratory collapse and death. Chemically, STX is stable, although it can be inactivated by treatment with strong alkali.
The saxitoxin ELISA is used for the quantitative analysis of saxitoxin in shellfish samples (mussel, scallop, oyster). The calibration curve is virtually linear in the range 0.005 to 0.2 ng/ml.
The kit uses a polyclonal rabbit antibody which shows the following cross-reactivities: saxitoxin (100%), decarbamoyl saxitoxin (19.2%), GTX5 (26.5%), gonyautoxins GTX2/3 (5.6%), neosaxitoxin (1.4%), and decarbamoyl neosaxitoxin (0.5%).
Detailed information of this ELISA is given in the Product Information Sheet.
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