Anthelmintics are drugs that are used to treat infections with parasitic worms. This includes both flat worms, e.g., flukes and tapeworms and round worms, i.e., nematodes. They are of huge importance for human tropical medicine and for veterinary medicine.
Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum anthelmintic medication. Ivermectin resistance in the nematode Haemonchus contortus has been reported in many parts of the world and many ivermectin resistant isolates have been found to have reduced sensitivity to moxidectin.
Moxidectin is a potent broad-spectrum endectocide of the macrocyclic lactone (macrolide) antimicrobial class. It is used for the prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for domestic pets, horses, cattle and sheep. It is also used for the prevention of red mite in caged birds.
For both ivermectin and moxidectin, Community MRLs have been established.