Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It consists predominantly of tylosin A (factor A) and varying amounts of tylosin factor B (desmycosin), tylosin factor C (macrosin) and tylosin factor D (relomycin), depending on the manufacturing source. Tylosin is active against Gram-positive bacteria, mycoplasmas and certain Gram-negative bacteria. Its action is mainly bacteriostatic. Tylosin has also shown to induce growth promotion when added at low levels in animal feeds.
Community MRLs have been established for tylosin in muscle (100 ng/g), fat (100 ng/g), liver (100 ng/g), kidneys (100 ng/g), milk (50 ng/g) and eggs (200 ng/g) for all food producing animals, including fish.
The tylosin ELISA is used for the quantitative analysis of tylosin residues in milk, honey and urine samples. The kit uses a polyclonal rabbit antibody which shows the following cross-reactivities: tylosin A (100%), tylosin B (36%), chloramphenicol (<0.01%), leucomalachite green (<0.01%), fluoroquinolones (<0.01%) and tetracyclines (<0.01%).
The limit of detection (LOD) is 3.3 ng/g for milk (dilution), 1.2 ng/g for honey (dilution) and 27.0 ng/g for urine samples (dilution).
Detailed information of this ELISA is given in the Product Information Sheet.
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